The Medical Research Foundation (MRF) has provided funding to establish HCV Research UK, a consortium of clinicians, scientists and epidemiologists.
The HCV Research UK consortium consists of over 30 co-applicants including:
- Universities in Scotland, England
- Liver centres in England
- Liver centres in Scotland
- Welcome Trust Sanger Institute
- Health Protection Scotland (HPS)
- Protection Health England (PHE)
- Hep C Trust
- British Liver Trust
Steering Committee and Collaborator
The members of the above HCV Research UK consortium have formed a Steering Committee that oversees all of its activities. Currently, there are 34 members on the Steering Committee who include representatives from many of the clinical centres involved in recruiting patients, the PHE and HPS and the patient support groups Hepatitis C Trust and the British Liver Trust.
- Adam Lawson - Royal Derby Hospital
- Andrew Fraser - Aberdeen Royal Infirmary
- Aravamuthan Sreedharan - Lincoln County Hospital
- Arvind Patel - MRC-Centre for Virus Research, Glasgow
- Andrew Langford - British Liver Trust
- Benjamin Stone - Royal Hallamshire Hospital
- Carl Anderson - The Wellcome Trust Sanger Institute
- Charles Gore – Hep C Trust
- David Goldberg - Health Protection Scotland
- David Mutimer - Queen Elizabeth Hospital, Birmingham
- Deirdre Kelly - Birmingham Children's Hospital
- Ellie Barnes – John Radcliffe Hospital
- Graeme Alexander - Addenbrooke's Hospital, Cambridge
- Graham Foster - The Royal London Hospital
- John Dillon - Ninewells Hospital, Dundee
- John McLauchlan - MRC-Centre for Virus Research, Glasgow
- Richard Myers – Health Protection England
- Keith Neal –Protection Health England
- Maggie Bassendine – Newcastle upon Tyne
- Stuart McPherson – Freeman Hospital, Newcastle upon Tyne
- Mark Thursz - Imperial College London & St Mary’s Hospital
- Martin Wiselka - Leicester Royal Infirmary
- Mary Ramsay - Protection Health England
- Matthew Cramp - Derriford Hospital, Plymouth
- Paul Kellam - Wellcome Trust Sanger Institute
- Peter Mills - Gartnavel General Hospital, Glasgow
- Peter Simmonds - Centre for Infectious Diseases, University of Edinburgh
- Philip Quinlan – Biobank, Ninewells Hospital, Dundee
- Peter Hayes - Royal Infirmary of Edinburgh
- Sharon Hutchinson - Health Protection Scotland, Glasgow
- Stefan Hubscher - University of Birmingham
- Stephen Ryder - Queen's Medical Centre, Nottingham
- William Rosenberg - Windeyer Institute of Medical Sciences, London and Royal Free Hospital
- William Irving – University of Nottingham
The clinics within hospital sites where recruitment of adult or paediatric patients occur are:
- Stephen Barclay – Glasgow Royal Infirmary
- Shouren Datta – Southern General Hospital, Glasgow
- Mathis Heydtmann – Royal Alexandra Hospital, Glasgow
- Salim Khakoo – Southampton General Hospital
- George Abouda – Hull Royal Infirmary
- David Chadwick – James Cook University Hospital, Middlesbrough
- Paul Richardson – Royal Liverpool Hospital
- Martin Prince – Manchester Royal Infirmary
- Mark Aldersley – St James’ University Hospital, Leeds
- David Gorard – Wycombe General Hospital
- Andrew Higham – Royal Lancaster Infirmary
- Yogi Reddy – Royal Blackburn Hospital
- Philip Shields – Royal Preston Hospital
- Christopher Shorrock – Blackpool Victoria Hospital
- Jeff Butterworth – Royal Shrewsbury Hospital
- Sulleman Moreea – Bradford Royal Infirmary
- Andrew Ustianowski – North Manchester General Hospital
- Raj Srirajaskanthan University Hospital Lewisham
- Richard Aspinall – Queen Alexandra Hospital, Portsmouth
- Neil Jenkins – Birmingham Heartlands Hospital
- Chin Lye Ch’ng – Singleton Hospital, Swansea
- Daniel Forton – St George’s Hospital, London
- Prof Deirdre Kelly - B’ham Children’s Hospital
- Dr Suzanne Davison - Leeds Children’s Hospital
- Dr Gareth Tudor-Williams - St Mary’s Paediatrics
- Dr Vas Novelli - Great Ormond Street Hospital
- Dr Sanjay Bansal - Kings College Hospital
- Dr Rosie Hague - Royal Hospital for Sick Children, Glasgow
- Dr Sabari Loganathan - Royal Aberdeen Children’s Hospital
- Dr Sabari Loganathan - Tayside Children’s Hospital
- Dr Laura Jones - Royal Hospital for Sick Children, Edinburgh
Day-to-day running of HCV Research UK is the responsibility of a Management Group who are supported by a Project Co-coordinator. There is also a Biobank Manager to oversee the transport, processing and storage of samples in the Biobank.
- Dr John McLauchlan – Co-lead of HCV Research UK and Director of the biorepository
- Prof Will Irving – Co-lead of HCV Research UK and responsible for the Clinical Research Database
- Dr John Dillon – Head of the Tissue and Data Access Committee
- Prof Graham Foster – Deputy Head of the Tissue and Data Access Committee
- Dr Sharon Hutchinson
- Mrs Bryony Wilkes – Project Co-ordinator
- Dr Sarah McDonald – Biobank Manager
The Clinical Research Database
The database holds a large set of anonymised information on patients recruited into the HCV Research UK cohort. Among the data are the following:
- Demographics – date and place of birth, gender, ethnicity, height, weight, BMI, soundex of surname and forename initial.
- Risk factors for HCV infection, and date(s) of first exposure to risk(s).
- History of past and current alcohol/smoking/cannabis intake
- Virology data – dates/results of all HCV, HBV, HIV tests.
- Other laboratory data – including full blood count, liver function tests, immunoglobulins, autoantibodies, HbA1c.
- Liver biopsy reports, including Ishak histological activity indices.
- Antiviral therapy – start/finish dates, modalities, reason for cessation, outcome and other medication.
- Disease outcomes – liver elasticity (fibroscan), clinical/histological diagnosis of cirrhosis, decompensation, hepatocellular carcinoma, liver transplantation, death certificate data.
The HCV Research UK Biobank is the facility where the clinical samples from each patient recruited into the cohort is stored. The main location for the Biobank is at the MRC-University of Glasgow Centre for Virus Research (CVR), Glasgow University with additional satellite storage sites at Nottingham University, Birmingham University and Oxford University. The Biobank Programme is managed from the CVR using a system that will log samples acquisition, location, usage and distribution to researchers. The route or travel for patient samples and anonymised information it displayed in the routes diagram.
Samples are sent from the above 43 adults and 9 paediatric patient recruitment UK sites - see map for locations of sites where patient samples are sent from. The samples stored at the Biobank will include plasma, serum, DNA and peripheral blood mononuclear cells (PBMCs) where all processing will be carried out at the CVR in Glasgow, or Birmingham. The samples are stored at -70oC until an application by a researcher for specially selected samples are made.